围绕华南地区主要水产养殖品种开展研究，在鱼粉替代、新型蛋白源开发及水产高脂饲料的开发方面获得以下成果，具体分为以下三个方面：

1. 系统研发了对虾低鱼粉微平衡饲料

鱼粉替代是目前水产动物营养领域的热点前沿问题，减少饲料鱼粉含量是发展环境友好型、经济节约型水产饲料的必经之路。被推荐人在水产领域最早开始系统性地研究低鱼粉条件下功能性非必需氨基酸（甘氨酸、脯氨酸和γ-氨基丁酸等）对凡纳滨对虾生长性能、饲料利用、肌肉组成和免疫反应的影响，并以此为基础系统研发了对虾低鱼粉微平衡饲料，将对虾鱼粉含量从25%降低至15%左右，目前已成功在凡纳滨对虾和斑节对虾上应用。在此基础上，继续研究了DHA和胆汁酸等功能性添加剂在低鱼粉饲料中的应用，利用全面的营养平衡将对虾饲料鱼粉含量进一步降低。

2. 系统评估了一批新型蛋白源在对虾饲料中的应用

被推荐人先后评估了甲烷氧化菌蛋白、黑水虻和乙醇梭菌蛋白等新型蛋白源替代饲料鱼粉对凡纳滨对虾生长性能、饲料利用、免疫性能、肠道健康和抗病力等方面的影响。新型蛋白源的开发对于减少水产动物对鱼粉等传统原料的依赖性、保护国家粮食安全具有重要意义。

3. 探究了高脂饲料诱发水产动物脂肪代谢异常和炎症反应的机制及缓解策略

增加饲料脂肪含量以有效提高蛋白质效率是近年来水产动物饲料的趋势，然而饲料脂肪含量过高容易诱发动物脂肪过度蓄积以及炎症反应。被推荐人先后研究了高脂饲料对大口黑鲈和珍珠龙胆石斑鱼生长性能、脂肪代谢、炎症反应和肠道菌群的影响。并探究了饲料中添加虾青素、绿原酸和胆汁酸对饲喂高脂饲料的水产动物的保护作用。以上研究将为水产动物高脂饲料的科学、高效、安全应用奠定理论基础。

1. Jia Xu, Xiaoyuc Li, Xinzhou Yao, Shiwei Xie*, Shuyan Chi, Shuang Zhang, Junming Cao, Beiping Tan*. Protective Effects of Bile Acids Against Hepatic Lipid Accumulation in Hybrid Grouper Fed a High-Lipid Diet. Frontiers in nutrition. 2022, 9, 813249.

2. Jia Xu, Shiwei Xie*, Shuyan Chi, Shuang Zhang, Junming Cao, Beiping Tan*. Protective effects of taurocholic acid on the excessive hepatic lipid accumulation via regulation of bile acids metabolism in grouper. Food & Function. 2022

3. Bocheng Huang, Shuang Zhang, Xiaohui Dong, Shuyan Chi, Qihui Yang, Hongyu Liu, Beiping Tan*, Shiwei Xie*. Effects of fishmeal replacement by black soldier fly on growth performance, digestive enzyme activity, intestine morphology, intestinal flora and immune response of pearl gentian grouper (Epinephelus fiiscogiittatus ♀ × Epinephelus lanceolatus ♂ ). Fish & Shellfish Immunology. 2022, 120, 497-506.

4. Jia Xu, Shiwei Xie*, Shuyan Chi, Shuang Zhang, Junming Cao, Beiping Tan*. Short-term dietary antibiotics altered the intestinal microbiota and improved the lipid metabolism in hybrid grouper fed medium and high-lipid diets. Aquaculture. 2022, 547, 737453.

5. Yongkang Chen, Shuyan Chi. Shiiang Zhang. Xiaohui Dong, Qihui Yang. Hongyu Liu. Beiping Tan*, Shiwei Xie*. Effect of black soldier fly (Hennetia illucens) larvae meal on lipid and glucose metabolism of Pacific white shrimp Litopenaeus vannamei. British Journal of Nutrition. 2021, )-15.

6. Yongkang Chen, Shuyan Chi, Shuang Zhang, Xiaohui Dong, Qihui Yang, Hongyu Liu. Beiping Tan*. Shiwei Xie*. Evaluation of Methanotroph (Methylococcus capsulatus、Bath) bacteria meal on body composition, lipid metabolism, protein synthesis and muscle metabolites of Pacific white shrimp (Litopenaeus vannamei). Aquaculture. 2022, 547, 737517.

7. Yongkang Chen, Shuyan Chi, Shuang Zhang, Xiaohui Dong, Qihui Yang, Hongyu Liu, Beiping Tan*, Shiwei Xie*. Evaluation of the Dietary Black Soldier Fly Larvae Meal (Hennetia illucens) on Growth Pcribnnancc, Intestinal Health, and Disease Resistance to Vibrio parahaemolyticus of the Pacific White Shrimp (Litopenaeus vannamei). Frontiers in Marine Science. 2021. 8. 1072.

8. Yongkang Chen, Shuyan Chi, Shiiang Zhang, Xiaohui Dong. Qihui Yang. Hongyu Liu, Wei Zhang. Junming Deng. Beiping Tan*, Shiwei Xie*. Replacement of fish meal with Methanotroph (Methylococcus capsulatus, Bath) bacteria meal in the diets of Pacific white shrimp (Litopenaeus vannamei). /Vquaculturc. 2021, 541, 736801

9. Shiwie Xie**, Peng Yin*, Lixia Tian, Yongjian Liu, Beiping Tan, Jin Niu. Interactions between dietary lipid levels and chronic exposure of legal aquaculture dose of suliamethoxazolc in juvenile largemouth bass Micropterus sahnoides. Aquatic Toxicology, 229 (2020), pp. 105670.

10. Shiwei, Xie*; Yongjian, Liu; Lixia, Tian: Jin, Niu*; Beiping Tan. Low Dietary Fish Meal Induced Endoplasmic Reticulum Stress and Impaired Phospholipids Metabolism in Juvenile Pacific White Shrimp. Litopenaeus vannamei. Frontiers in Physiology. 2020. 01024.